Results at St Leonards-Mayfield School have improved for the fourth year running.
It said almost 60 per cent of its Year 13 students achieved A*-A grades.
This was particularly impressive given that the school’s intake was not highly selective, the school explained.
There was a 100 per cent pass rate with 94 per cent scoring between A* and C grades and 84 per cent achieving at least one A*/A grade.
Results in maths, chemistry, physics and biology – subjects traditionally viewed as a male preserve - were particularly impressive.
Half of the year 13 girls taking mathematics were awarded A* with 80 per cent attaining A* in further mathematics.
A total of 75 per cent of physics grades were A*.
Mayfield’s outstanding ceramics department also had another successful year, with all of its candidates recording A* or A and the consistently strong department of geography saw 85 per cent and English 84 per cent of students achieving the highest grades.
All of the six Mayfield girls offered Oxbridge places succeeded in meeting or surpassing their target grades.
Sixteen year old Moji Agboola attained five A* grades and will be reading engineering at Peterhouse, Cambridge.
A spokesperson for the school said: “Clearly she has proved worthy of the two scholarships the college and the University awarded her.”
Julia Laskowska also achieved five A* and will be reading economics at Sidney Sussex College.
Ellie Cox, winner of a Nuffield Scholarship and a finalist in the UK Young Scientist of the Year, (who joined Mayfield in the Sixth Form) attained four A* and is taking up her place to read medicine at Emmanuel College.
Jenny Shepherd (four A*) from Five Ashes will be reading engineering at Emmanuel College and Ella Strudley (three A*) from Stone Cross near Crowborough will read natural sciences at Clare College.
Both girls joined in Year 9. In addition to scientific endeavours all three have played a leading role in the orchestra and wider musical life of the school.
Deputy head girl Hannah Gilliland (two A*, two A) from Stonegate, who has been at Mayfield since Year 7 and a stalwart of school netball and hockey teams will read human, social and political science at Newnham College.
Head girl Catriona Franck (three A*) (from Tunbridge Wells, and now Switzerland), will be reading PPE at Warwick University.
Flora Hickish (two A*, one A) from Hailsham will read biological science at Durham.
Marianna Balzarelli (two A*, one A) from Wadhurst will be reading medicine at Birmingham.
Crystal Zhang (three A*, one A) is reading maths at Imperial College, London.
Nina Bolger (two A*, two A) from Mayfield is reading veterinary science at Bristol.
Elsa Lao and Christine Ling are both going to the London School of Economics.