Newick musicians Josh Pewter and Stuart Payton will begin their ‘Open Mic Challenge’ on Monday.
Cycling more than 300 miles in five days from East Sussex to Cornwall, they will be performing music gigs at venues along the route.
It’s all to raise money for St Peter and St James Hospice, based in North Chailey.
When most bands decide to go on tour, it usually involves driving their equipment around in vans and staying in hotel suites.
The acoustic duo will be cycling with guitars, clothing and equipment upon their bikes, and camping overnight to complete the challenge. The route will take them across the length of southern England, finishing in the surfing town of Newquay.
Josh said: “We wanted to accomplish a new feat, which was both unusual and challenging.
“I feel the combination of an endurance event and music will hopefully encourage people to get behind us and donate to a great cause; it’s certainly the closest we’ll ever get to a UK tour!
“We will be giving it everything, both on the bike and on the stage, for five days straight.”
Donations as sponsorship can be made at uk.virginmoneygiving.com/OpenMicChallenge