More than 13 people applied for every vacancy when a store advertised for workers in Hailsham.
The new Tesco Express store received more than 250 applications for 18 new jobs.
Tesco interviewed and recruited staff from the area to work in the South Road store.
Store manager, Nikki Taylor, and her team promoted the new jobs online.
She said: “I was thrilled by the response we received to our recruitment drive.
“In this time of economic uncertainty, it is great that we are able to create jobs for our local community and help get people back into work.
“I am really pleased with my new team and I’m looking forward to working with them. We are delighted to be opening a Tesco Express store on South Road and look forward to playing an active role in the local community.”
The store will open seven days a week from 6am until 11pm, and boasts self-service tills, mobile phone top-up facility, bakery, beers, wines and spirits.