For the third year running more than 60 per cent of students studying at Seaford Head School achieved five A*-C including English and maths with 94 per cent securing five A* to C.
The school said it was especially delighted with the performance in many individual subjects and in the success of its students.
There was a 100 per cent pass rate in AS geography and level 3 IT and a 90 per cent pass rate in AS art.
A spokesperson for the school said: “Congratulations to all those Year 11 students who worked so hard to achieve these level three results a year early.”
At GCSE, a total of 100 per cent of students achieved an A*, A or B grade in French and 88 per cent achieved an A*to C grade in Spanish.
All BTEC students secured their grades.
As a specialist school for science and sport Seaford Head said it was very proud of the results in these two areas.
GCSE biology, PE and the Sports Diploma all achieved an excellent 100 per cent A*-C pass rate and more than 90 per cent of students achieved an A* to C in chemistry and physics.
Other notable achievements at GCSE were more than 90 per cent A* to C pass rates in English language, business and communications studies and media studies.
Many subjects achieved a high percentage of A*-A grades.
These were French (75 per cent), biology (70 per cent), chemistry (62 per cent), physics (53 per cent), Spanish (33 per cent) and Religious Studies (31 per cent).
Individual students did exceptionally well with 40 students achieving eight A* to A grades and the following achieving 14 or more A* to A grades; Ishtiaq Ali, Jemima Breeds, Emily Harmer, Samuel Kelly, Madeline Lambert, Anna Osborne, Jessica Russell and Alexander Stonard.
The spokesperson added: “The staff and governors would like to congratulate all Seaford Head students on their achievements this year and wish them well with the next stage of their education and/or training.”