Warwick Road in Seaford will close for several months to allow work on the £6m new library and social care development to continue.
The road will be closed from February 13 until December 20, 2013.
People who live in Warwick Road will have vehicle access but other drivers will be diverted via Broad Street (north) and Avondale Road. Access for pedestrians will be maintained via Warwick Road to Sutton Park Road and Stafford Road.
East Sussex County Council apologised for any inconvenience this may cause.