One person died and more than 20 people were injured at work in Wealden in the last year according to figures released by the Health and Safety Executive (HSE).
Figures for 2012/13 show an increase in fatal injuries in the work place in Wealden on the previous 12 months but a decrease in non-fatal injuries with 21 last year compared to 35 in 2011/12.
The HSE said the person who died in Wealden fell from a height while working in construction.
Across East Sussex there were 188 non-fatal major injuries compared to 224 major injuries across the border in West Sussex. But there were no fatal injuries in West Sussex.
In the South East in total 22 people lost their lives while at work in 2012/13 and 2,702 suffered a major injury. This is compared to 17 deaths and 3,005 major injuries the previous year.
Since the figures were released the HSE has issued an appeal to businesses to take steps to ensure safety at work.
Mike Wilcock, HSE head of operations for the South East, said: “The families of those South East workers who lost their lives last year had to face Christmas without them, and hundreds of other workers have had their lives changed forever by a major injury.
“Whilst the number of workplace deaths has decreased nationally, they have increased across the South East counties, and it serves as a stark reminder of why we need good health and safety in workplaces.
“I therefore urge employers to spend their time tackling the real dangers that workers face, and to stop worrying about trivial matters or pointless paperwork.
“It’s important to remember that while we still have one of the lowest rates of workplace deaths in Europe, one death is still one too many. I would urge businesses to focus on helping to cut the number of deaths in 2014.”
The figures show Brighton has some of the highest major injuries with 63 non-fatal injuries last year.
In Mid Sussex there were 34 major injuries at work.
The figures were represented as rates per 100,000 employees.
The Health and Safety Executive said research shows the difference between injury rates at regional and local level are strongly influenced by variations in the mix of different industries and occupations in different areas and the different rates of reporting.
The figures only relate to injuries reported under Riddor (Reporting of Injuries, Diseases and Dangerous Occurrences Regulations) where the HSE puts duties on employers to report certain serious workplace incidents.