The government body has sought a temporary traffic regulation order (TTRO) which, if granted, would allow it to close a section of the A27 at any time over an 18-month period from March 2.
The proposed work is expected to last about 11 weeks, with night-time closures from 8pm to 6am.
The highways maintenance would see roadside barriers installed along both carriageways between the Crossbush Roundabout and Offington Lane Roundabout, Worthing – including all slip roads, bus stops and side roads.
A Highways England spokesman said the scope of the work and traffic management required was unclear, as the granting of a TTRO was the first step in the process.
It is unconfirmed whether the section of road could be closed in sections or in its entirety.