Sussex Roads Police said all four were spotted on the A27 between Fishbourne and Emsworth on Saturday morning (February 13).
In a Tweet, police included a picture which showed speeds of 105mph, 106mph, 109mph and 111mph.
The incidents come just days after a 25-year-old man died in a collision on the A27 at the Sussex and Hampshire border.
Sussex Roads Police added: “Even more disappointing is the fact that as each one put their foot down they passed signs from a crash earlier this week where a young man lost his life.”
A black Volkswagen Golf was travelling east towards Chichester when it crashed into the central reservation at 11.40pm on Wednesday.
The driver – a 25-year-old man from Havant – was sadly pronounced dead at scene.
The passenger – a 19-year-old man from Havant – suffered life-threatening injuries and remains in hospital in a serious but stable condition.
A 20-year-old woman and a 23-year-old man, both from Havant, were arrested on suspicion of causing death by dangerous driving. They have since been released on conditional bail until 10 March, pending further enquiries.
The road was closed in both directions for several hours while investigations were carried out.
Police are appealing for witnesses and are particularly interested to hear from anyone with dash cam footage of the collision, or the Golf or a red Audi A3 being driven in the area prior to the collision.
Please call 101 or email [email protected] quoting Operation Westdown.