Mother-of-two Georgina, 31, was last seen leaving the Clifton Food and Wine off licence store in Clifton Road, Worthing, at 9.30am on Wednesday, March 7.
Her mother Andrea Gharsallah has been campaigning tirelessly to find her, but leads have dried up.
She now believes her daughter could have fallen prey to human traffickers, whether it is drug or sex trafficking.
On Friday, she said: "I fear that something like trafficking may be what has happened to her.
"Where is she? How has nobody seen her? It’s impossible. It’s been 324 days and we’ve not seen her.
"It’s 46 weeks and two days missing - each day is harder and harder, and each day we hold on to hope. What else do we have?
"My daughter just vanished without a trace."
Since Georgina disappeared, Andrea and Georgina’s sister Arij appeared on This Morning on ITV to raise the profile of the disappearance, and have covered Worthing with missing posters, including Broadwater Bridge where there was a rumoured sighting of her.
If you have seen Georgina, call Call 101 Quoting OPERATION PAVO or contact the Missing People charity.