The crash was reported near the roundabout at the junction of Shoreham High Street and the Norfolk Bridge shortly after 3pm.
A283 Old Shoreham Road was partially blocked northbound, resulting in slow, queuing traffic.
Emergency services were pictured at the scene.
Sussex Police confirmed offices were sent to the scene.
Firefighters were also called to assist.
A spokesperson for West Sussex Fire & Rescue Service said: “One crew from Shoreham was sent to the incident.
“On arrival there was a road traffic collision involving one bus and scaffolding. Crews are currently liaising with a specialist who is on site.
“There are no reported injuries.”
Elsewhere, delays were said to be increasing on A27 Upper Brighton Road westbound between A270 Upper Shoreham Road (Southwick / Holmbush turn off) and Grand Avenue.
Delays have also been reported on A27 Old Shoreham Road westbound at A2025 Grinstead Lane (Sompting roundabout), with the 'usual delays heading towards Worthing'.
Reportedly, there is also traffic congestion on A24 Broadwater Street West southbound at A27 Upper Brighton Road (Grove Lodge roundabout).
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