Fatima Mohamed-Ali went missing from her home in Park Drive Close, Newhaven, police have said.
The 52-year-old is believed to have left her house on foot sometime between 7.30am and 3.15pm, leaving her handbag and other personal items behind.
Police said she has been described as Indian, 5’ 2”, of slim build with shoulder-length black hair worn in a ponytail. She is likely to be wearing traditional Indian dress.
Inspector Dan Eagle said: “Fatima’s family are understandably very worried about her and we have launched a full search for her in the Newhaven area, supported by volunteers from Sussex Search and Rescue (SusSAR).
“If you have seen her at any time since Friday morning, please let us know immediately by calling 101 quoting serial 946 of 12/02. If you see her, please dial 999 immediately.”
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