This is due to engineering work taking place between Crawley and Horsham closing all lines.
An amended service will also run between Southampton / Portsmouth / Littlehampton and London Victoria, Southern said.
Customers are advised to plan their journey using the National Rail Enquiries Journey Planner.
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Meanwhile, the A272 at Cowfold remains closed for emergency repairs between Picts Lane and Wineham Lane – after a lorry overturned on Thursday night – spilling tar onto the road.
The road closure is affecting traffic between Cowfold and Bolney.