Police, the fire service and Southern Gas engineers have been working through the night to stop the leak, outside Asda in Ferring, and say the road will be reopened as soon as the scene is made safe.
Emergency services were called at 6pm yesterday, Saturday, January 21, though people have reported a strong smell of gas in the area from 2pm.
The Asda Superstore was evacuated last night as a precaution and currently remains closed.
The A259 currently remains closed in both directions between the Titnore Lane roundabout and the Angmering bypass roundabout.
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