Shoreham RNLI Lifeboat Station was called to the incident at about 5pm.
A spokesman for the station said a man had been pulled from the river by a member of the public.
He was brought back to the station by crews for treatment and has since been taken to hospital for further checks, the spokesman added.
The team also rescued another man from the water in East Worthing a few hours before.
Related stories: UPDATE: Lifeboat called after person pulled from river Adur
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