Emergency services were called to the collision in London Road, Arundel, at around 3.30pm.
Sussex Police said the collision involved a BMW and a Mitsubishi and a man and woman had been injured and taken to hospital.
A spokesman for South East Coast Ambulance Service said: “We sent an ambulance and critical care paramedic to the scene.
“Three people were reported initially – two men and a woman – and two were taken to hospital.
“A man in his 40s was taken to St Richard’s with potential pelvic injuries, while a second patient also taken to hospital.”
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