Three vehicles collided about a mile before the Fishbourne roundabout on the eastbound A27 between Emsworth and Chichester at 7.40am.
The eastbound carriageway was temporarily shut and drivers advised to avoid the area if possible.
Reports suggested traffic queues on the A259 and A27 stretched back miles to Emsworth.
Emergency services attended at the scene. Police said there have been no reports of serious injuries at this stage.
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