Kevin Pietersen is named in a Surrey T20 squad for the first time this season but Kumar Sangakkara is unavailable having returned to Sri Lanka for their upcoming Test Series against Pakistan.
Sussex are second from bottom in the group, with two wins from five matches, while Surrey are bottom, with one win from five games.
The match starts at 2.30pm and a crowd of 8,000 is expected.
Sussex then entertain Durham in County Championship Division 1 from Monday to Thursday, with an 11am start each day.
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