Graham Potter's men are just two points above the relegation zone, while Arsenal are ninth and still have an outside chance of Champions League football.
Last December at the Emirates, Brighton enjoyed one of the best results of their season thanks to a 2-1 victory. Adam Webster gave Albion a deserved lead in the first half but Alexandre Lacazette levelled just after the break. Brighton pushed for the winner and got their reward when Neal Mauapy expertly headed home Aaron Mooy's cross with 10 minutes remaining.
Another three points would be a huge boost for the Albion, who have yet to record a victory in 2020. Their last win was a 2-0 victory against Bournemouth at the Amex last December.
Arsenal were on a decent run of form just before the lockdown and won their last three home matches against West Ham, Everton and Newcastle.
Brighton do however have a good record against Arsenal. The Gunners are yet to win at the Amex in the Premier League, having lost 2-1 and drew 1-1 on their previous visits to the south coast.
Pierre-Emerick Aubameyang is clearly one to watch for Arsenal, the striker has 17 goals to his name this season, while Neal Maupay leads the way for Albion with eight goals. Nicolas Pépé was finding form before the lockdown and his pace, skill and six assists make him quite a threat. Pascal Gross has the most assists for Albion with four.
Referee: Martin Atkinson. Assistants: Stuart Burt, Peter Kirkup. Fourth official: Keith Stroud. VAR: Michael Oliver. Assistant VAR: Richard West.
The match will be broadcast on BT Sport. All remaining 92 top flight fixtures will be broadcast live on Sky Sports, BT Sport, BBC Sport or Amazon Prime.
Sky Sports will make 25 of the remaining top-flight matches free to air. Amazon Prime's four matches will also be broadcast for free.
Which games are free to air and where to watch?...Here's the full list
Wednesday, 17 June: Aston Villa v Sheffield United (18:00), Sky Sports. Manchester City v Arsenal (20:15), Sky Sports.
Friday, 19 June: Norwich v Southampton (18:00), Sky Sports and Pick. Tottenham v Manchester United (20:15), Sky Sports.
Saturday, 20 June: Watford v Leicester City (12:30), BT Sport. Brighton v Arsenal (15:00), BT Sport. West Ham v Wolves (17:30), Sky Sports. Bournemouth v Crystal Palace (19:45), BBC.
Sunday, 21 June: Newcastle v Sheffield United (14:00), Sky Sports and Pick. Aston Villa v Chelsea (16:15), Sky Sports. Everton v Liverpool (19:00), Sky Sports and Pick.
Monday, 22 June: Manchester City v Burnley (20:00), Sky Sports.
Tuesday, 23 June: Leicester v Brighton (18:00), Sky Sports. Tottenham v West Ham (20:15), Sky Sports.
Wednesday, 24 June: Manchester United v Sheffield United (18:00), Sky Sports and Pick. Newcastle v Aston Villa (18:00), BT Sport. Norwich v Everton (18:00), BBC. Wolves v Bournemouth (18:00), BT Sport. Liverpool v Crystal Palace (20:15), Sky Sports.
Thursday, 25 June: Burnley v Watford (18:00), Sky Sports and Pick. Southampton v Arsenal (18:00), Sky Sports. Chelsea v Manchester (20:15), BT Sport.
Saturday, 27 June: Aston Villa v Wolves (12:30), BT Sport.
Sunday, 28 June: Watford v Southampton (16:30), Sky Sports and Pick.
Monday, 29 June: Crystal Palace v Burnley (20:00), Amazon Prime.
Tuesday, 30 June: Brighton v Manchester United (20:15), Sky Sports and Pick.
Wednesday, 1 July: Bournemouth v Newcastle (18:00), Sky Sports and Pick. Arsenal v Norwich (18:00), BT Sport. Everton v Leicester (18:00), Sky Sports. West Ham v Chelsea (20:15), Sky Sports.
Thursday, 2 July: Sheffield United v Tottenham (18:00), Sky Sports. Manchester City v Liverpool (20:15), Sky Sports.
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