Albion's form has dipped alarmingly in recent matches with defeats to Manchester United, Burnley, Aston Villa, Newcastle and Liverpool.
Graham Potter's team have scored just once and conceded 11 in that losing streak and the head coach admits he is under pressure to turn results around.
Brighton are set to be without Adam Lallana once again as they host Antonio Conte's men.
The former England international was forced off with a tight hamstring just eight minutes after coming on as a substitute against Liverpool on Saturday.
Defender Adam Webster is the Seagulls’ only other notable absentee with a groin injury.
Potter know's Tottenham pose a genuine threat, having lost 3-1 to Conte's men in the FA Cup earlier this season.
"We had a fair experience of what they’re like in the cup," Potter said. "A tough game, they’re a good side, Antonio [Conte] has done a fantastic job, I am big fan of his in terms of how his career has developed and what he has achieved at Tottenham, you can see the way the team acts, he’s a fantastic coach.
"Then they’ve got top players like Heung-min Son and Harry Kane, it’s a Premier League partnership that’s up there with the greats, so it’s a tough challenge, we need our supporters with us, we need to be fighting, we need to be lucky, we need all those things."
Scroll down and click through. Here's how Brighton could line-up for this one.
1. Rob Sanchez
Fortunate to remain on the pitch against Liverpool and needs a big performance against Kane and co
2. Joel Veltman
The reliable Netherlands international set to take his place on the right side of the defensive three
3. Lewis Dunk
Will be at the heart of the defence. Getting back to his best after injury and suspension
4. Marc Cucurella
The Spaniard is likely to continue his role on the left side of the trio