Albion required extra-time and penalties to see-off Newport County in the previous round and will hope for a a slightly easier time against Neil Critichley's team who are 16th in League One.
The winner of today will face an away trip at either Leicester or Brentford.
Brighton have a few injuries to contend with and Graham Potter will also have one eye on Wednesday's night's crucial Premier League clash against relegation rivals Fulham.
South African striker Percy Tau could once again be set to start, while Polish international midfielder Jakub Moder could make his debut at some stage.
Scroll down and click through to see how Albion could line-up at the Amex.
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South African striker Percy Tau looks set for a starting role against Blackpool
. Christian Walton
The 25-year-old keeper from Truro could well be in line for his first start under Graham Potter. Jason Steele, who saved four penalties in the shootout at Newport is ill, Robert Sanchez will likely be rested ahead of Albion's Wednesday night clash against Fulham and Maty Ryan moved on loan to Arsenal yesterday. Big chance for Walton.
. Joel Veltman
The Dutchman has settled in well to the team since his bargain 900k summer arrival. If Potter goes with the back four, expect the 29 year-old to feature at right back.
1. Christian Walton
The 25-year-old keeper from Truro could well be in line for his first start under Graham Potter. Jason Steele, who saved four penalties in the shootout at Newport is ill, Robert Sanchez will likely be rested ahead of Albion's Wednesday night clash against Fulham and Maty Ryan moved on loan to Arsenal yesterday. Big chance for Walton.
2. Joel Veltman
The Dutchman has settled in well to the team since his bargain 900k summer arrival. If Potter goes with the back four, expect the 29 year-old to feature at right back.
3. Lewis Dunk
The Albion skipper has been in top form of late and despite a huge match against Fulham on Wednesday, I expect Dunk to be at the heart of the defence to face Blackpool
4. Adam Webster
Seems to get better with every match this season and was arguably Albion's man of the match at Leeds. I expect Webster to play once again today and feel Graham Potter will perhaps rest Ben White, who played in midfield on a heavy pitch at Leeds.