Brighton, who have 10 points from their first 10 matches, have a few injury concerns ahead of this south coast showdown.
Former Saint Adam Lallana looks set to miss out as he continues to recover from a groin problem. Lallana lasted just eight minutes against Liverpool as he came on as a second half substitute for Aaron Connolly but soon disappeared back down the tunnel.
Neal Maupay is hoping to be fit after tweaking a hamstring shortly after missing a penalty against Liverpool last week, while Tariq Lamptey is available for selection once more after his one match ban
Scroll down and click through to see how Graham Potter's men may line-up against eighth placed Southampton.
1. Maty Ryan
Produced that stunning stop against Southampton last season at St Mary's.. Responded well to the disappointment of being dropped at Spurs. The Aussie international will need to be on his toes tonight especially with lethal freekicks from JWP.
2. Ben White
Will likely be on the right side of the defensive trio. Has been excellent this season and little wonder the likes of Liverpool and Chelsea continue to be linked.
3. Lewis Dunk
The Brighton skipper is back in the groove after his three match ban. Looked a little rusty in the early stages against Aston Villa but the victory at Villa Park and more minutes under his belt against Liverpool will have done him the world of good
4. Adam Webster
Wasn't convinced about him on the left side of the defensive three but he has adapted well. A good display against Liverpool last week and his distribution was better too