Defender Andreas Christensen will miss out again for Chelsea due to coronavirus isolation and Trevoh Chalobah remains sidelined with a thigh problem, with Reece James a longer-term absentee due to a hamstring injury.
Ben Chilwell is out for the season after knee surgery, with Edouard Mendy at the Africa Cup of Nations with Senegal.
Tuchel's men could be in for a tough evening as Brighton for the most part outplayed Chelsea at Stamford last month and came away with a 1-1 draw thanks to a late header from veteran striker Danny Welbeck.
Brighton duo Shane Duffy and Adam Lallana are major doubts due to respective ankle and hamstring injuries.
Captain Lewis Dunk is closing in on a return from a knee problem but will not be involved, while midfielders Enock Mwepu (hamstring) and Yves Bissouma (Africa Cup of Nations) also remain unavailable.
Full-back Tariq Lamptey is fit to take on his former club after a slight groin issue restricted him to a second-half cameo during Friday’s 1-1 draw with Crystal Palace.
Here's how Chelsea could line-up for this one...
Kepa Arrizabalaga: The Spanish goalkeeper will continue between the sticks as Mendy is away on international duty at the Africa Cup of Nations
Malang Sarr: The defender could be drafted in a Tuchel deals with a host of defensive absentees
Thiago Silva: The Brazilian's vast experience adds control and composure to the Chelsea defence
Antonio Rüdiger: The competitive German should enjoy a feisty evening against Albion's lively striker Neal Maupay
César Azpilicueta: Now 32 but remains a brilliant Premier League defender
Ngolo Kante: What team wouldn't want an Ngolo Kante in their midfield?
Jorginho: Just don't give away a penalty with this guy on the pitch.
Alonso: Adds balance on the left and always a danger from set-pieces
Mason Mount: The England man could be back in the starting line-up and is always a threat. Presses, tackles, assists and scores - the full package
Rom Lukaku: Criticised of late but the £90-odd million striker remains a potent threat
Timo Werner: Never quite shown his best form at Chelsea but has bags of pace and will be one Albion will have to watch closely