2,500 home fans will be allowed in to attend the game as part of a government-backed trial to begin the process of allowing supporters back into stadiums.
Brighton's first team squad have been away on a pre-season training camp and tomorrow's match will offer Albion a chance to test themselves against Frank Lampard's Chelsea.
It could be a first run-out at the Amex for new signings Adam Lallana and Joel Veltman, while Ben White could also get a chance to stretch his legs following his return from loan at Leeds United.
Graham Potter will however be without midfielder Aaron Mooy who today completed a surprise switch to Chinese Super League club Shanghai SIPG.
Chelsea have also had a busy transfer window this summer and the Amex friendly could mean a first outing in a Blues shirt for Timo Werner and Hakim Ziyech.
Other new signings, Ben Chilwell, Malang Sarr and Thiago Silva are unlikely to feature but returning loanee Ethan Ampadu could be back.
Albion’s friendly against Chelsea on Saturday will be available to watch for free on MyAlbion TV.
The Amex will host the first football match open to supporters since March after government approval, with Albion fans snapping up tickets for the fixture.
But if you can’t be there, the game will be available on MyAlbion TV, which you can access through the club's official website.
Brighton will also host Chelsea on September 14 for Albion's first match of the 2020/21 Premier League campaign.