Albion will search for their third consecutive Premier League win, having recording victories in their last two outing against Southampton and Newcastle.
Man United at Old Trafford will however be a stern test for Graham Potter's team as Ole Gunnar Solskjaer's men are second in the Premier League standings and will be keen cement their place in the top four.
Brighton have worries of a different kind. Despite some impressive displays this season Albion remain involved in a relegation tussle and are six points above 18th placed Fulham.
Albion were also desperately unlucky not to take anything from the reverse fixture earlier this season when Man United netted a controversial 100th minute winner from the penalty spot.
It was a crazy match that saw Leo Trssard hit the wood work three times for Albion, Neal Maupay net a Peneka penalty, Marcus Rashford fire home a belter and a decider from Bruno Fernandes in the 10th minute of stoppage time.
What time does Man United and Brighton kick off?
The game kicks off on Sunday, April 4 at 7.30pm at Old Trafford
Is the game on TV?
Yes. The match will be broadcast live on BT Sport 1
Can I stream Man U v Brighton & Hove Albion for free?
EE customers can get a free three-month trial of BT Sport by texting SPORT to 150.
At the end of the three months, you will automatically roll onto the £15 per month subscription.
Or you can cancel the trial at any time during the three months by texting STOP SPORT to 150.
What’s the team news?
Brighton will hope to have Adam Webster available as he continues his recovery from an ankle injury. Aaron Connolly (calf/back/rib) will also be assessed ahead of the match after he returned home early from international duty with Ireland. Solly March (knee) and Tariq Lamptey (hamstring) remain sidelined.
Marcus Rashford (ankle) will hope to available for Man United while Anthony Martial (knee) will also be assessed. Juan Mata will also hope to return following the international break.
Who is the referee?
Referee: Mike Dean. Assistants: Darren Cann, Dan Robathan. Fourth official: Andy Madley. VAR: Peter Bankes. Assistant VAR: Matthew Wilkes.
What are the odds for Man U v Brighton & Hove Albion?
At the time of writing, bookmakers have Brighton priced at 19/4 to win the clash.
A draw is 57/17, whilst a Man U win is 4/6.
Sky Bet are offering a odds of 10/3 on Red Devils star Bruno Fernandes to score first.
Brighton’s Neal Maupay to score first is priced at 7/1 currently, with Danny Welbeck at 10/1.
All odds correct at the time of writing. Over 18s only. Please gamble responsibly and Be Gamble Aware. www.begambleaware.org.Read also: Brighton could offload nine stars this summer - including Percy Tau and Shane Duffy | Brighton's dream starting line-up for next season - with two shrewd summer transfers | Adam Lallana explains why improving Brighton can win at Manchester United