The Hammers are firmly in the hunt for European football, lying in sixth place in the Premier League ahead of their trip to the south coast.
Declan Rice could return for West Ham after six weeks out with a knee injury. Aaron Cresswell should also be fit despite limping off in last weekend’s defeat by Everton.
But Mark Noble, Arthur Masuaku and Manuel Lanzini are injury doubts.
Former Brighton loanee Jesse Lingard also looks set to play a key role for West Ham once more.
Scroll down and click through to see how West Ham could line-up against the Seagulls.
But Mark Noble, Arthur Masuaku and Manuel Lanzini are injury doubts.
5. Aaron Cresswell
A classy performer this season for West Ham on the left side of the defence. Dangerous from set pieces.
6. Soucek
A powerful performer in the West Ham midfield and very useful in the air
7. Declan Rice
The return from injury of their star midfielder is a huge boost for the Hammers
8. Jarrod Bowen
Adds an attacking threat and an often underrated player for West Ham