After a goalless first half, goals from George Francomb, Max Watters (2) and Tyler Frost handed them a 4-0 win against the Shrimps.
And Reds fans took to social media to hail the result.
On the Crawley Town FC Supporters Group Facebook page, Lee Wesson said: "Best 45 minutes in years."
Daniel Järnström said: "Well someone had to knock those overachievers back down to earth. Great result!"
Stephen Brian Brown posted: "Fantastic big win of Crawley. Outstanding."
James Charlton said: "Losing to Cheltenham was never really a shocker as they are a decent side. Morecambe were never going to be top of the table material as the season went on."
Michael Fox tweeted: "Some lovely possession football that 2nd half and much more purpose and energy than recently, cracking performance and goals. Some competition up front as well now!"