The Seagulls drew 0-0 with Championship side West Brom in the FA Cup fourth round on Saturday, after Premier League defeats to Liverpool and Manchester United.
Fulham are winless in four matches and sit second from bottom in the Premier League, seven points from safety.
Brighton are 13th, seven points clear of the relegation zone.
What time does Fulham v Brighton kick off?
Kick-off at Craven Cottage is 7.45pm on Tuesday. The Seagulls have won their last three games at Fulham (2-0, 2-1 and 2-1).
Is the game on TV?
No. Albion are not on television again until the home match with Burnley on February 9.
Highlights of Tuesday's match will be on Match of the Day on BBC One from 10.45pm on Wednesday evening.
What’s the team news?
Defender Alfie Mawson is ruled out for Fulham, while forward Aboubakar Kamara has reportedly been suspended by the Cottagers.
Sergio Rico has taken over as number one at Fulham, with Fabri and Marcus Bettinelli also having played in the Premier League this campaign.
Aleksandar Mitrovic is Fulham's top scorer with eight goals, while Andre Schurrle has netted six times.
Former Liverpool winger Ryan Babel made his Cottagers debut in their 2-1 defeat to Tottenham last time out.
Goalkeeper Mathew Ryan will be back available for Brighton are returning from the Asian Cup after Australia lost in the quarter-finals last week.
Albion will make several changes from the 0-0 FA Cup draw with West Brom on Saturday, with Lewis Dunk, Gaetan Bong, Davy Propper, Pascal Gross and Solly March all likely to come back into the starting line-up.
Bernardo and Jose Izquierdo have missed the last four and ten matches respectively. Chris Hughton will provide an update on the duo at his pre-match press conference tomorrow.
Alireza Jahanbakhsh is still with Iran at the Asian Cup.
Who is the referee?
Lee Probert will be the man in the middle at Craven Cottage. He has shown 28 yellow cards and three reds in ten Premier League matches this season.
The assistant referees will be Andy Garratt and Adrian Holmes, with Roger East the fourth official.
What are the odds?
Fulham are favourites for the three points on PaddyPower at 13/10. A Brighton win is 23/10 and the draw is 21/10.
A repeat of the 2-2 draw between the sides is 14/1, while Brighton to win 2-1 is 9/1. Fulham to win by the same scoreline is 17/2.
Fulham top-scorer Alexsandar Mitrovic is 9/2 to score the first goal and 6/4 to net anytime.
Albion top-scorer Glenn Murray is also 9/2 to score the opener and is 13/8 to strike at anytime. Seagulls forward Florin Andone is 5/1 and 9/5 respectively.
Fulham forward Andre Schurrle is 11/2 to score first and 2/1 anytime, with Ryan Babel 15/2 and 13/5 respectively.
Brighton defender Shane Duffy, who has four goals this season, is 22/1 to score first and 9/1 to net anytime.