A collision between a car and bike was reported, in Upper Brighton Road, at 4.20pm on Thursday (September 24).
An air ambulance has landed nearby, and Sussex Police and South East Coast Ambulance Service have also been photographed at the scene.
Firefighters also joined the emergency response.
A West Sussex Fire and Rescue Service (WSFRS) spokesperson said: “Joint Fire Control mobilised two fire engines and a heavy rescue tender to the scene. Upon arrival firefighters used hydraulic rescue equipment to extricate one person.
“Firefighters remain on scene at this time, and drivers are urged to avoid the area for the time being.”
The road was temporarily blocked between Grove Lodge Roundabout and First Avenue.
An alert from AA Traffic News read: “Road blocked and queueing traffic due to crash on A27 Upper Brighton Road Eastbound from A24 Broadwater Street West (Grove Lodge Roundabout) to First Avenue.”
An eye-witness said they saw police officers reopening the road at 6.20pm.
This was confirmed by Sussex Traffic Watch, at 7.10pm. The A27 was then reported as cleared and reopened between the Grove Lodge roundabout and Lyons Farm lights.
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1. Worthing A27 blocked following collision
Air ambulance on the scene Photo: Sussex News and Pictures
2. Worthing A27 blocked following collision
Emergency services on the scene Photo: Sussex News and Pictures
3. Worthing A27 blocked following collision
Emergency services on the scene Photo: Sussex News and Pictures