Bruno Silva, who owns a group of dental practices across Sussex, is the new tenant for the upstairs office space in the centre, which has been vacant since 2006.
The space, which is around 7,000 square feet, will be turned into a 13-chair practice, with ‘world class’ facilities.
Mr Silva said: “We knew the site was the right location the minute we saw the space. It’s huge and has a lot of potential.
“It is not confirmed, but we think that it will be the largest dental practice in the UK.”
Mr Silva’s current Worthing practice is based in Liverpool Gardens, but in recent times, its growth has demanded expansion.
When a planning application to extend the practice failed, Worthing Borough Council recommended the Guildbourne Centre as an option.
Mr Silva said: “Planning and getting the necessary approvals has taken a long time, but I am pleased to say that we are now making good progress with building works.
“We initially made a planning application to expand the practice into South Field House, just across the road, but this fell through.”
For the full story, see the Worthing Herald, out Thursday, September 12.