AA Traffic News said at 3.06pm that two cars were involved in the incident, which had affected the A26 both ways from the Barcombe turn off to Isfield Road.
They added: “There is an air ambulance on scene.”
For more updates from AA Traffic News take a look at their live map at www.theaa.com/route-planner/traffic-news.
Sussex Police have been approached for comment.
1. A26 collision
The A26 near Barcombe is closed this evening (Thursday, April 13) after reports of a serious crash Photo: Dan Jessup
2. A26 collision
The A26 near Barcombe is closed this evening (Thursday, April 13) after reports of a serious crash Photo: Dan Jessup
3. A26 collision
The A26 near Barcombe is closed this evening (Thursday, April 13) after reports of a serious crash Photo: Dan Jessup
4. A26 collision
The A26 near Barcombe is closed this evening (Thursday, April 13) after reports of a serious crash Photo: Dan Jessup