Both lanes have been closed near Polegate between Drusillas Park and the junction with the A2270 Eastbourne Road following reports of a collision involving a car and a van.
Elsewhere in Eastbourne there are temporary traffic signals due to construction on A259 Pevensey Bay Road at Tanbridge Road.
There are also temporary traffic signals due to gas main work on Rattle Road near Wood Sage Way and on Coopers Hill in Church Street.
In Hastings there are temporary traffic signals due to gas main work on A259 Old London Road between High Street and Ashburnham Road.
Over in Brighton, St James Street has been closed in both directions since around 6.30am after a 'police incident'.
There are also narrow lanes due to construction on A259 Kings Road around A2010 West Street. Outside the Odeon.
In Worthing there are temporary traffic signals due to telecoms work on A259 Goring Road at Shaftesbury Avenue and further west along the A259 through East Preston.
Gas works have also started near Union Place, with temporary traffic lights in place.
In Chichester there are temporary traffic signals due to water main work on Carlisle Gardens at Norwich Road.
At Pease Pottage there are temporary traffic signals due to water main work on Barn Close at Horsham Road.
In Horsham the B2195 Harwood Road is closed both ways between Horsham Train Station and Kings Road due to main water works by Southern Water.
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