Albion's new head coach Fabian Hurzeler has some key decisions to make ahead of his first match in charge at the Amex Stadium.
Villareal, who finished eighth in La Liga last term, will offer a stern test ahead of their Premier League opener at Everton next Saturday on August 17.
Hurzeler has a number of players who have yet to feature in pre-season, including skipper Lewis Dunk and Scotland international midfielder Billy Gilmour.
Dunk and Gilmour were given extended leave following Euro 2024 but both should feature against the Spaniards, despite the uncertainty around Gilmour's future. The 23-year-old is wanted by Napoli and Serie A club are expected to return with increased bids between now and the end of the transfer window.
Here's how Albion could line-up for their final pre-season friendly against Villarreal.
9. Mats Wieffer - CM
The £25m summer arrival will look to crank up his fitness in the final pre-season clash. Fans will be excited to see him for the first time. Photo: Warren Little
10. Yankuba Minteh - RW
Brighton fans will get there first glimpse of one of the most exciting transfers of the window following his £30m switch from Newcastle. Has looked great in pre-season so far. Photo: Masashi Hara
11. Kaoru Mitoma - LW
Getting back to his best in pre-season after his back injury. Expect him play 45 minutes or an hour on the flank ahead of Everton Photo: Masashi Hara
12. Danny Welbeck - CF
Expect Welbeck to lead the line but Joao Pedro could make his first appearance of pe-season in the second half as the Brazilian works his way back to fitness. Photo: George Wood