Albion, who impressed on Tuesday night as they earned a 0-0 draw at Chelsea, are seven points above the drop zone with six matches remaining.
Brighton defender Ben White will serve a one-match suspension following his red card in the midweek draw at Chelsea.
Forward Percy Tau could return to the squad after being absent at Stamford Bridge due to a tight hamstring.
Tariq Lamptey (hamstring) and Solly March (knee) remain out.
Scroll down and click through to see our predicted starting XI for Bramall Lane
9. Alexis Mac Allister
Back in the team at Stamford Bridge and a very hardworking display against Chelsea. Give Albion options and could play higher up the pitch at Sheffield United
10. Leo Trossard
A fairly quiet game at Chelsea but Brighton should have more possession at Sheffield United and Trossard will look to have a greater influence
11. Neal Maupay
On the bench at Chelsea with perhaps this game in mind. Welbeck may not be quite fit enough which could see Maupay lead the line. Scored a vital goal at Bramall Lane last season in a 1-1 draw