Albion travel to the City Ground bidding to resume their push for Europe following an agonising FA Cup semi-final loss to Manchester United.
Wednesday evening’s clash with relegation-threatened Forest marks the start of nine Premier League games in just under five weeks for the eighth-placed Seagulls.
De Zerbi is determined to make history by bringing continental football to Sussex and help ease the pain of Sunday’s penalty shoot-out loss at Wembley.
“We are still disappointed for the result,” the Brighton boss said of the 7-6 spot-kick defeat.
“We played a fantastic game. We gave our best and we lost the game.
“We have to be stronger, we have to play tomorrow with the same passion, with the same attitude, with the same quality because we have another nine games, very important for us.”
As injuries bite, here’s how Brighton could line-up for this one...
De Zerbi is determined to make history by bringing continental football to Sussex and help ease the pain of Sunday’s penalty shoot-out loss at Wembley.
![The Ecuador international will take his usual slot on the left flank.](https://www.sussexexpress.co.uk/webimg/b25lY21zOjFlZDYxMTNmLWMyZTItNDllMS05OTk5LWRiZWU0YjFhNmVlZjo1OWM0NTYwYy0wYjE3LTRjMDQtOWU4NC02MjhjY2E3ZjgwZDU=.jpg?crop=3:2&width=594)
5. Pervis Estupinan
The Ecuador international will take his usual slot on the left flank. Photo: Mike Hewitt
![If he isn't used at right back the versatile German will be vital in the central areas of midfield](https://www.sussexexpress.co.uk/webimg/b25lY21zOmIwMWQ2NGY4LTg3YTktNDNmNS1hNTFmLTc4NDg5YjM4ZGFlNjo0MjlhNDczZS05Y2NmLTQ5MWItYTc1YS0zZjlmYWViZmUyZjE=.jpg?crop=3:2&width=594)
6. Pascal Gross
If he isn't used at right back the versatile German will be vital in the central areas of midfield Photo: Clive Rose
![Played brilliantly against United at Wembley and will have to go again at Nottingham Forest. Brighton certainly getting value for money from him ahead of the summer](https://www.sussexexpress.co.uk/webimg/b25lY21zOjUwMWUzYWFjLThiNDAtNGQyNi05MWQ0LTY1NDI2ZTE1OGJkMDpkMmFhOGZlNi00Mzk4LTQ3ODAtOGVhNy1kMTRmZDkzMTBmNWE=.jpg?crop=3:2&width=594)
7. Moises Caicedo - M
Played brilliantly against United at Wembley and will have to go again at Nottingham Forest. Brighton certainly getting value for money from him ahead of the summer Photo: Mike Hewitt
![De Zerbi confirmed the winger will play and the head coach look for a positive response after his penalty miss against United](https://www.sussexexpress.co.uk/webimg/b25lY21zOmIzNjZmZDNmLTE5NzctNGQ2Zi1iY2FmLTcyN2I5ZDRmOTBjNjo3ODI3N2QzOC0wZDZkLTQyYzEtYWM5Mi01MzFjMTI2ODBmOTY=.jpg?crop=3:2&width=594)
8. Solly March - RW
De Zerbi confirmed the winger will play and the head coach look for a positive response after his penalty miss against United Photo: Clive Rose