The Mali international was a key man for Potter since he arrived at the club in 2019.
Bissouma added skill, drive and power to the Albion line-up but moved to Tottenham earlier this window in a £30m deal.
Potter, who steered Brighton to their highest ever ninth place in the Premier League last season, will now assess his midfield talent ahead of the Premier League opener at Old Trafford.
The likes of Enock Mwepu, Moises Caicedo, Adam Lallana, Pascal Gross and Steven Alzate will all be vying for midfield spots, and should help to cushion the blow of Bissouma’s exit.
Albion have also been linked with a move for Austrian international midfielder Florian Grillitsch, who is a free agent after leaving Hoffenhiem.
Potter will however be without Poland international midfielder Jakub Moder, who continues his recovery from a serious ACL injury.
“Midfield is a strong area for us,”Potter said. “Hopefully the players we have can take the space that Yves has left.
“We know the quality of Yves and we wish him well with his new chapter in his life and his career, but that’s football - life goes on.
“We’ve also got some good young players and a nice mix of people in that area. So we’re looking forward to seeing how that manifests itself.”
Check out the latest Premier League transfer speculation below...
1. Price set for Kean
Juventus have set an asking price of £29m for Aston Villa target Moise Kean this summer, but any transfer would be ‘extremely complicated’ to agree. (CalcioMercato)
2. Man Utd want Neto
Manchester United have reportedly identified Wolves winger Pedro Neto as an alternative to Ajax’s Antony this summer. (Fichajes)
3. Blues in Fofana talks
Chelsea have opened talks with Leicester City over defender Wesley Fofana, despite the Foxes’ £70m asking price. (Football.London)
4. Winks interest cools
Leeds United and Everton have both backed off in their respective pursuits of Tottenham midfielder Harry Winks. (The Athletic)