In a match that has produced rivalry between fans in recent years, the Seagulls will take on the Eagles with just three points separating the two sides.
Brighton are sitting in 16th position at the moment with 26 points from 24 games following a 0-0 draw over Aston Villa last time out.
Palace, however, occupy 14th with 29 points from their 24 fixtures after a poor 3-0 loss to Burnley in their last Premier League outing.
Fans will also be able to watch the game on TV – for full details click here.
In terms of team news, Wilfred Zaha is sidelined with a knee injury which could mean Jean-Philippe Mateta starts.
Gary Cahill and Andros Townsend are among a number of players who will expect to return after the loss to Burnley.
James McCarthy has returned to training this week, putting the midfielder in line to feature in the squad.
But what about the rest of Roy Hodgson’s potential starting XI?
Here, we predict how the former Liverpool and England boss could line-up ahead of tonight’s clash with Graham Potter’s side: