The defender picked up a hip problem in the bruising midweek draw with Southampton but boss Graham Potter is hopeful he will be passed fit.
Alireza Jahanbakhsh (hamstring) has returned to training and should be available but Steven Alzate (groin) and Jose Izquierdo (knee) remain sidelined for the Seagulls, who need a point to be mathematically safe from relegation.
Speaking on Saturday, Potter said: "We understand the the fight that we've had to go through, the work that we've done to get to this point.
"So at the start of lockdown, I think we were two points above and certainly if you looked at our games, and I'm sure the experts out there would have said well they're hard to pick up points, etc.
"We've done quite well. not perfectly, of course, but we've done quite well in terms of extending our lead and now we're at a point where one more result gets us over the line which would be a fantastic achievement for us.
"37 points so far, I want to try and get as close to 43 as we can for six points to play for that's gonna be the aim."
Injury problems are mounting for Newcastle head coach Steve Bruce with defender Fabian Schar (dislocated shoulder) added to an already long list.
Winger Allan Saint-Maximin (calf) is a doubt with defenders Jamaal Lascelles and Ciaran Clark (both ankle), Florian Lejeune (thigh), Paul Dummett (Achilles) and midfielders Isaac Hayden and Sean Longstaff (both hamstring) and striker Andy Carroll (hip) all nursing injuries.
Left-back Danny Rose returns to the squad having been ineligible against his parent club Tottenham in midweek.
On Brighton's progress under Potter this season, Bruce said, "“It’s fascinating to watch. Graham has come in from Chris, who did a wonderful job over the years, and obviously has a different approach and style.
"They’ve totally changed their whole philosophy. Looking from afar, for Brighton to stay in the division is always going to be their first and foremost. They’ve done okay.”
Brighton provisional squad: Ryan, Button, Lamptey, Montoya, Dunk, Webster, Duffy, Burn, Bernardo, Propper, Stephens, Mooy, Bissouma, Gross, March, Mac Allister, Jahanbakhsh, Trossard, Connolly, Maupay, Murray.
Newcastle provisional squad: Dubravka, Darlow, Yedlin, Krafth, Rose, Lazaro, Manquillo, Fernandez, Bentaleb, Shelvey, M Longstaff, Ritchie, Saint-Maximin, Allan, Young, Almiron, Joelinton, Gayle, Muto, Watts.
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