The Japan international has impressed as a second half substitute against Liverpool and Spurs and is pushing hard for a starting role this Friday at Brentford.
So far, De Zerbi has opted for Danny Welbeck and Leandro Trossard as his main attacking threat with Solly March and Pervis Estupiñán providing width from the flanks.
Mitoma's displays however maybe enough to convince De Zerbi into a reshuffle in order to accommodate the dynamic 25-year-old.
Tariq Lamptey is another also looking for increased game time. The wing back can add some pace and added excitement to the team but – like Mitoma – has so far been limited to bursts from the bench.
“Mitoma is a very good player," De Zerbi said. "He and Adam Lallana changed the game against Liverpool and this was the same.
“I want to find a way to put on the pitch all the players who have quality - but I can only play 11.
“He is a great guy, a great player and in the future we can change positions – not style – but it’s difficult to find the best solution because (Leandro) Trossard is a very good player, (Solly) March too.”
Here's how Albion could line-up with a 3-4-2-1 at Brentford - if Mitoma and Lamptey are included.
1. Rob Sanchez - GK
Gaining in experience all the time. Played well against Tottenham and De Zerbi will be keen to see his distribution and playing out from the back improve further Photo: Mike Hewitt
2. Joel Veltman - D
Remains a solid and consistent performer on the right side of Albion's back three. Photo: Clive Brunskill
3. Lewis Dunk - D
De Zerbi has already singled out influential skipper Dunk for special praise since his arrival. Remains the rock in this Albion team Photo: Mike Hewitt
4. Adam Webster - D
Webster Improves with every game. Keen to put his injuries issues behind and perhaps get in the England conversation once more Photo: Steve Bardens