Two Albion men limped off during last weekend’s 2-1 win over Chelsea, while goalkeeper Jason Steele sat out that game with a minor issue.
De Zerbi previously confirmed back-up keeper Robert Sanchez, who lost his place to Steele at the beginning of last month but played at Stamford Bridge, will start against United.
The Italian praised the Spain international’s response to being dropped and his desire to become better at playing out from the back with his feet.
“Robert showed he is improving because in Stamford Bridge he played very well, better than in the last period,” said De Zerbi.
“I think my request is not so difficult. I don’t want to take a risk, but I want to play with the ball always in every situation, with every result, in every stadium, with every opponent.
“I think he understood my idea, my vision, what I want on the pitch. He answered in the right way, working harder than the past and he’s improving for it.”
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The Italian praised the Spain international’s response to being dropped and his desire to become better at playing out from the back with his feet.