Brighton are just one point above the drop zone and still seek their first victory and clean sheet of 2020.
Shane Duffy is available once more having missed the Palace defeat due to family reasons and Dale Stephens will hope to force his way into the starting XI having fully recovered from a groin problem.
Alexis Mac Allister, who was recalled early from his loan at Boca Juniors, has yet to feature in the match day squad and so too Tariq Lamptey, who joined on transfer deadline day from Chelsea. Both new arrivals will hope to be involved at Molineux Stadium.
Wolves have impressed this season and Nuno Espírito Santo's team are pushing for a Champions League spot with 10 matches of the Premier League campaign remaining. Last weekend they proved too strong for Jose Mourinho's Spurs, beating them 3-2.
Potter however is encouraged by the spirit shown by the Albion players in training, despite their painful loss to old rivals Palace. Watford beating Liverpool and West Ham's victory against Southampton also made the relegation scrap much tighter.
"Everything has got closer there is no point denying that," said Potter. "We have to do the things that we need to do. We are at the business end of the season. We have got 10 games to go, 30 points for play for and we need to show that fight and character.
"There is no point thinking about what the other teams do. If we don't get ourselves right it is of no importance. We focus on ourselves, we don't rely on anybody else and try to win the next game.
"The players were disappointed and hurt by the Palace result. The want to respond and want to improve. They want to fight their way out for the situation they are in."
Albion drew 2-2 with Wolves earlier this season and Potter was full of praise for their achievements and results this season. Their attacking trio of Raul Jimenez, Diogo Jota, and Adama Traore have also caused problems for many Premier League defences and Brighton will have to be at their best to stop them.
“I think they have done amazing," said the Albion head coach. "Full credit has to go to Nuno his success of promotion and then stabilising in the Premier League, plus the European run they are on to still maintain a level is very impressive.
"They have some really good players, are really well organised and they are a top team competing for a Champions League place really alongside what they are doing in the Europa League, so they had an amazing season.
"He (Traore) is not the only one. Their front three are really good (Raul) Jimenez as a nine and (Diego) Jota on the other side, a real mix of attacking play and qualities.
"This is backed up with two midfielder player that really know the game and have a fantastic tactical understanding and then an organisation defensively, so they have got a good mix, good quality and they are a top team.”