The Bees, Championship champions Norwich City and runners-up Watford are all coming up whilst relegated trio Sheffield United, West Brom and Fulham are all demoted to the second tier.
Brighton finished 16th in the top flight last time out but where are the Seagulls predicted to finish in their record breaking fifth campaign.
Based on the bookmakers odds for the 2021-22 top flight title, the Brighton Indy runs through where the odds compilers are predicting each team to finish in reverse order, from bottom to top.
The fixtures for the new season are being unveiled at 9am on Wednesday, June 16.
17. Southampton
The Saints finished the season in 15th but are 17th in the betting market for the 2020-21 Premier League campaign at a best priced 1500-1 though as short as 200s and seventh favorites to go down at 5-1.
18. Brentford
The play-off winners are also 11-10 to be relegated and 1500-1 to win the division with one firm. Others go 500s or 1000-1. Could they be the surprise package coming up?
19. Watford
The Championship runners-up are joint second favourites to go down at 11-10 and are 1500-1 to win the division with five firms.
20. Norwich
They might have gone up as Championship champions but the Canaries are even money favourites to go straight back down and 1500-1 with six firms to win the division.