The two sides may not be the closest in terms of geography, but there is still no shortage of bad blood between them – and it’s a grudge that is made all the more fierce by the need for points to ensure their respective Premier League statuses next season.
The reverse fixture at Selhurst Park ended 1-1 back in October, with Alexis Mac Allister scoring a last minute equaliser to cancel out Wilfried Zaha’s first half opener.
It’s been a little while since Albion took all three points from this one, however, and the Seagulls haven’t beaten the Eagles since March 2019, with Glenn Murray and Anthony Knockaert on the score-sheet that day
But this is a rivalry that stretches back way beyond the past couple of years or so.
The first official meeting between Brighton and Crystal Palace came on Christmas Day 1920, in a 2-0 defeat for Albion in the old Division Three South.
In the years since, the sides have met on 103 other occasions, but who has had the better of the clashes, and how does it rank in terms of ferocity compared to some of the biggest rivalries in English football?
Paddy Power have ran the numbers, comparing win percentages from derby clashes between every Premier League club and their most fierce foes to determine which clashes truly are the most competitive.
Click and scroll through the pages below to read our countdown...
. LIVERPOOL, ENGLAND - FEBRUARY 07: A general view of the Nike Flight yellow match ball placed on a training cone during the Premier League match between Liverpool and Manchester City at Anfield on February 07, 2021 in Liverpool, England. Sporting stadiums around the UK remain under strict restrictions due to the Coronavirus Pandemic as Government social distancing laws prohibit fans inside venues resulting in games being played behind closed doors (Photo by Jon Super - Pool/Getty Images)
Premier League match ball. (Photo by Jon Super - Pool/Getty Images) Photo: Pool
. Fulham vs Chelsea
Matches: 86 Fulham win %: 12.8% Chelsea win : 57% Win % difference: 44.2% (Photo by Carl Recine - Pool/Getty Images) Photo: Pool
. Southampton vs Portsmouth
Matches: 71 Southampton win %: 49.3% Portsmouth win %: 29.6% Win % difference: 19.7% (Photo by ANDY RAIN/POOL/AFP via Getty Images) Photo: ANDY RAIN
1. Fulham vs Chelsea
Matches: 86 Fulham win %: 12.8% Chelsea win : 57% Win % difference: 44.2% (Photo by Carl Recine - Pool/Getty Images) Photo: Pool
2. Southampton vs Portsmouth
Matches: 71 Southampton win %: 49.3% Portsmouth win %: 29.6% Win % difference: 19.7% (Photo by ANDY RAIN/POOL/AFP via Getty Images) Photo: ANDY RAIN
3. Leeds United vs Manchester United
Matches: 108 Leeds win %: 24.1% Man United win %: 43.5% Win % difference: 19.4% (Photo by Adam Davy - Pool/Getty Images) Photo: Pool
4. Aston Villa vs Birmingham City
Matches: 128 Aston Villa win %: 44.5% Birmingham win %: 29.7% Win % difference: 14.8% (Photo by Clive Mason/Getty Images) Photo: Clive Mason