Calderwood was assistant to Hughton at Newcastle United, Birmingham City and Norwich City, having previously been in charge of Northampton Town and Nottingham Forest; he also managed Hibernian between spells at Newcastle and Birmingham.
The 50-year-old Scot played more than 600 league matches for Mansfield Town, Swindon Town, Tottenham Hotspur, Aston Villa, Forest and Notts County - and won 36 international caps - during a 20-year playing career.
Meanwhile, Hughton has confirmed that Nathan Jones (first-team coach) Antti Niemi (goalkeeping coach), Joaquin Gomez (coach), Adam Brett (head of medical services) and Tom Barnden (fitness coach) complete the first-team coaching and backroom set-up.
He said, “It was always my intention to bring somebody in to work alongside myself and Nathan. What I wanted to do is give myself some time to get to know the staff here: not only the coaching staff but also the backroom team, before finalising that decision.
“I’m delighted Colin is coming in. He is someone I have worked with before, and I know him well, and we wanted to bring someone in of Colin’s experience.
“I know that he will work well with the existing coaching staff at the club and I think he’ll be a very good addition to the coaching team.”
Calderwood begins work with Albion this week, and his first game alongside Hughton in the Albion dugout will be against former club Nottingham Forest at the Amex this Saturday.