The draw was broadcast by BBC Sussex Radio on Saturday 10 November 2018 and also on Twitter.
Larette Tritton, Assistant Designated Safeguarding Officer of Sussex County FA drew the home team, and Ken Benham, Chief Executive of Sussex County FA drew the away teams.
The following ties were drawn:
Little Common vs. Haywards Heath TownHastings United vs. Brighton & Hove Albion or LewesEast Grinstead Town vs. AFC VarndeaniansPagham vs. Burgess Hill TownEast Preston vs. Chichester CityBognor Regis Town vs. Three BridgesHorsham vs. Eastbourne BoroughEastbourne Town vs. Worthing
Fixtures are to be played on or before Wednesday 5 December 2018.