There will be more than 20 stalls at the centre, in Croft Avenue, Southwick, all individually picked due to the quality of their stock.
Organiser Jeannette Jones explained the stallholders were independent traders for companies that do not sell on the high street, or local crafters who had made their own stock to sell.
She added: “Each stall is different, as I do not think it fair to the trader or the customer to have duplicate stock.
“Last year, £2,500 was raised. This pays for this centre to be open for just over a week, so I would like to try to better this this year.”
Stalls include woodcraft, Fairtrade metalwork, soaps, textiles, handbags, Indian jewellery and ceramics.
Refreshments will be available and there will be face painting for the children, as well as a tombola and raffle.
East Worthing and Shoreham MP Tim Loughton will open the fayre at 10am on the Saturday and the event will be open 10am to 4pm both days.
Entry is free, but donations are appreciated.