They were given an early advantage when Mason Holgate’s horrific challenge on Kaoru Mitoma resulted a red card for the defender.
Albion took full advantage with goals from Facundo Buonanotte, Danny Welbeck, Simon Andrinag, who got a brace, and an own goal.
The 5-0 win took Roberto De Zerbi's men up to seventh in the Premier League table.
Here is a gallery of pictures from the game.
5. Sheffield United v Brighton and Hove Albion in the Premier League
Danny Welbeck of Brighton & Hove Albion runs with the ball during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by David Rogers/Getty Images) Photo: David Rogers
6. Sheffield United v Brighton and Hove Albion in the Premier League
Facundo Buonanotte of Brighton & Hove Albion scores his team's first goal during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
7. Sheffield United v Brighton and Hove Albion in the Premier League
Chris Wilder, Manager of Sheffield United, looks on during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by David Rogers/Getty Images) Photo: David Rogers
8. Sheffield United v Brighton and Hove Albion in the Premier League
Lewis Dunk celebrates after Facundo Buonanotte of Brighton & Hove Albion scored his team's first goal with teammates during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty