They were given an early advantage when Mason Holgate’s horrific challenge on Kaoru Mitoma resulted a red card for the defender.
Albion took full advantage with goals from Facundo Buonanotte, Danny Welbeck, Simon Andrinag, who got a brace, and an own goal.
The 5-0 win took Roberto De Zerbi's men up to seventh in the Premier League table.
Here is a gallery of pictures from the game.
13. Sheffield United v Brighton and Hove Albion in the Premier League
SHEFFIELD, ENGLAND - FEBRUARY 18: Vinicius Souza looks dejected after an own goal by Jack Robinson of Sheffield United (obscured) during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
14. Sheffield United v Brighton and Hove Albion in the Premier League
SHEFFIELD, ENGLAND - FEBRUARY 18: Simon Adingra of Brighton & Hove Albion celebrates scoring his team's fourth goal during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by David Rogers/Getty Images) Photo: David Rogers
15. Sheffield United v Brighton and Hove Albion in the Premier League
SHEFFIELD, ENGLAND - FEBRUARY 18: Simon Adingra of Brighton & Hove Albion celebrates with the fans scoring his team's fourth goal during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
16. Sheffield United v Brighton and Hove Albion in the Premier League
SHEFFIELD, ENGLAND - FEBRUARY 18: Simon Adingra of Brighton & Hove Albion scores his team's fifth goal during the Premier League match between Sheffield United and Brighton & Hove Albion at Bramall Lane on February 18, 2024 in Sheffield, England. (Photo by David Rogers/Getty Images) Photo: David Rogers