The Seagull's flying start to the season sees them heading into the game in a Champions League spot, and Graham Potter' s side will be eager to keep their fine run of form going with another big result as the season's first quarter nears its close.
Speaking after last weekend's goalless draw with Norwich City, Potter said: "I thought maybe in the final third we struggled a little bit. We didn’t have the decision making, we lacked a bit of width and an ability to attack the back line.
“It was a tricky game, against a back five with Norwich fighting for points. and it was never going to be straightforward. We did some things well but didn’t play well enough to get the three points.”
“If the referee on pitch doesn’t give it (Neal Maupay's appeal for a penalty) it’s a tough one for VAR to overrule, but I haven’t seen it back closely.”
Meanwhile, speaking ahead of the clash against City, Brighton defender Dan Burn said: “We will prepare and we are high on confidence. That win against them last season was huge for us.
“We have been quite consistent in our performances against them over the last couple of seasons but haven’t picked up the results. To put in the performance we did and pick up the win is a massive confidence-booster and it will take us into the game.”
Take a look at all the latest news from the Premier League, as the reaction to last weekend's exhilarating action continues:

1. Toffees ready £10m raid
Everton are thought to be ready to reignite their interest in Rangers right-back Nathan Patterson, after having a £5m offer turned down for the player next summer. They've been tipped to return with a bid in the region of £10m. (Daily Record) Photo: Ian MacNicol

2. Foxes eye Brazilian midfielder
Leicester City are said to be keeping tabs on Porto midfielder Otavio, and are believed to have scouted him during his side's game against 1-0 win over AC Milan last night. His release clause will drop to €40m next summer. (Sport Witness) Photo: MIGUEL RIOPA

3. PSG plot Salah raid
PSG have reportedly already set their sights on their marquee signing for next summer, with Liverpool's Mohamed Salah and Borussia Dortmund's Erling Haaland top of their wish list. The former has already scored 13 goals in ten games this season. (Mirror) Photo: David Ramos

4. Reds could re-sign Sterling
Liverpool have been tipped to make a sensational swoop for their former star Raheem Sterling, as the Man City ace continues to be linked with a move away from the club. PSG and Barcelona have also been muted as potential destinations for the Euro 2020 star. (Bild) Photo: Alex Livesey

