The Seagull's flying start to the season sees them heading into the game in a Champions League spot, and Graham Potter' s side will be eager to keep their fine run of form going with another big result as the season's first quarter nears its close.
Speaking after last weekend's goalless draw with Norwich City, Potter said: "I thought maybe in the final third we struggled a little bit. We didn’t have the decision making, we lacked a bit of width and an ability to attack the back line.
“It was a tricky game, against a back five with Norwich fighting for points. and it was never going to be straightforward. We did some things well but didn’t play well enough to get the three points.”
“If the referee on pitch doesn’t give it (Neal Maupay's appeal for a penalty) it’s a tough one for VAR to overrule, but I haven’t seen it back closely.”
Meanwhile, speaking ahead of the clash against City, Brighton defender Dan Burn said: “We will prepare and we are high on confidence. That win against them last season was huge for us.
“We have been quite consistent in our performances against them over the last couple of seasons but haven’t picked up the results. To put in the performance we did and pick up the win is a massive confidence-booster and it will take us into the game.”
Take a look at all the latest news from the Premier League, as the reaction to last weekend's exhilarating action continues:

5. Magpies join race for DCL
Newcastle United have been linked with a move for Everton striker Dominic Calvert-Lewin, as they look to flex their new financial muscle in January. The England international netted 21 goals for his side last season, and has also been linked with Arsenal and Man Utd. (Telegraph) Photo: Mike Hewitt

6. Real Madrid challenge Chelsea for Kounde
Real Madrid could be set to challenge Chelsea for the signature of Sevilla's Jules Kounde, as interest continues to grow in the versatile defender. The Blues had a £42m offer rejected for the 22-year-old last summer. (Daily Mail) Photo: FRANCK FIFE

7. Magpies favourites to sign Barkley
Amid speculation that Ross Barkley could leave Chelsea in January, Newcastle United have been named favourites to sign him - just ahead of Leeds United. Burnley are trailing behind as third favourites to sign the ex-Everton star. (Various) Photo: Alex Burstow

8. Foxes sensation knocks back new deal
Leicester City midfielder Youri Tielemans is believed to have turned down a contract extension. The Man Utd and Liverpool linked star is now "weighing up his options", with his current deal expiring in 2023. He joined the Foxes for £40m back in 2019. (90min) Photo: Alex Pantling

