Brighton have beaten Southampton and Newcastle in their previous two top flight encounters and a first ever victory at Old Trafford would pull Potter's team further away from the relegation places.
In will be no easy task however as United are second in the league standings and three points for Ole Gunnar Solskjaer's team would boost their chances of a top four finish.
Albion will be without defenders Adam Webster and Dan Burn for this one and will hope Jakub Moder and Leo Trossard can continue their fine form.
Scroll down and click through to see our predicted starting XI.
5. Pascal Gross
One of Brighton's most consistent performers in the midfield. The German covers so much ground and capable of top quality deliveries into the box from set pieces and open play
6. Adam Lallana
Looks fit and back his best. Has been excellent in the past three matches and Brighton will need his experience and guile at Old Trafford.
7. Yves Bissouma
Offers a defensive balance to the Brighton midfield. Has previously been linked with a move to United with many of their fans believing he's an upgrade on their midfield pivot, Fred.
8. Jakub Moder
Scored a fine goal for poland against England in midweek and will be looking to take that form to Old Trafford. Impressed on his first PL start against Newcastle and should keep his place at United